Authors: Joseph Clark Shettima1
Abstract
The adhesion of hydrogels to biological tissues is a longstanding challenge in tissue engineering,
implantable devices, and surgical adhesives. Hydrogel-based materials are favored for their
biocompatibility, flexibility, and similarity to soft tissues; however, their poor adhesion limits their
application in regenerative medicine and surgical procedures. Recent advancements, such as the use of
silica nanoparticles, have shown promise in enhancing hydrogel-tissue adhesion through blood
coagulation mechanisms, forming a natural adhesive joint at the tissue interface (Michel et al., 2020).
This research aims to optimize silica nanoparticle coatings to enhance adhesion strength under dynamic
in vivo conditions, investigate the underlying mechanisms of blood coagulation, and evaluate long-term
biointegration. The results are expected to provide breakthroughs in hydrogel-based materials for tissue
repair, surgical adhesives, and hemostatic agents.
